by Jessica Lao | Aug 2, 2018 | Pancreatitis |
Perlara and Mission: Cure – a nonprofit organization with a mission to find a cure for those affected by pancreatitis – recently launched a Pancreatitis PerlQuest partnership. Ethan covers the backstory of this partnership – from the initial intro to...
by Jessica Lao | May 8, 2018 | PMM2-CDG |
Drug repurposing screen in haploid PMM2-CDG yeast models During Stage 1 of our PerlQuest partnership with Maggie’s Cure, we generated haploid PMM2-CDG yeast models of three pathogenic variants: F119L, R141H, and V231M. We expressed these variants in the yeast...
by Jessica Lao | Jan 29, 2018 | PMM2-CDG |
A goal of Stage 1 of our PMM2-CDG PerlQuest with Maggie’s Cure is to identify yeast models that are suitable for use in screens for small molecules that rescue PMM2 deficiency. As described below, we successfully developed screen-ready yeast models that mirror two...
