by Nina DiPrimio | May 17, 2016 | Uncategorized |
It has been a while since you have heard from me. We are deep in post screen characterization of our NPC hits so I thought I would take a step back to the beginning to discuss NPC disease biology. We focused a bit on the cholesterol and lipid metabolism aspects of...
by Nina DiPrimio | Dec 14, 2015 | Uncategorized |
To continue on the theme of understanding your compound of interest’s mechanism of action, let’s discuss target identification (ID). You have just completed your screen and found a hit, but now you want to learn more about why it is a hit. As mentioned before,...
by Nina DiPrimio | Nov 22, 2015 | Uncategorized |
As the cell biology lead at Perlstein Lab, I spend a lot of time thinking about ways to better understand the mechanism of action of the hits from our primary screens. There are many experiments one can do to try to narrow down what pathway their compound is affecting...
by Nina DiPrimio | Oct 26, 2015 | Uncategorized |
Biomarkers for NPC How will investigators, clinicians and patients know if their therapeutic for the treatment of NPC is efficacious? In this blog post we will explore a few of the potential biomarkers that can be used to monitor disease progression in patients with...
by Nina DiPrimio | Sep 23, 2015 | Uncategorized |
This post is based on a publication from Nicholas Cianciola out of the Carlin Lab at Case Western. For my previous post, I wrote about the relationship between Niemann-Pick C and viral pathogenesis. I am going to continue that thread by talking about another virus...
