by Ethan Perlstein | Jul 31, 2018 | Pancreatitis |
Earlier this month we announced our 7th PerlQuest! Our new Pancreatitis PerlQuest partnership is with Mission: Cure, a nonprofit organization whose mission is to find a cure and improve the quality of life of those affected by pancreatitis and, in the process,...
by Jessica Lao | May 8, 2018 | PMM2-CDG |
Drug repurposing screen in haploid PMM2-CDG yeast models During Stage 1 of our PerlQuest partnership with Maggie’s Cure, we generated haploid PMM2-CDG yeast models of three pathogenic variants: F119L, R141H, and V231M. We expressed these variants in the yeast...
by Jessica Lao | Jan 29, 2018 | PMM2-CDG |
A goal of Stage 1 of our PMM2-CDG PerlQuest with Maggie’s Cure is to identify yeast models that are suitable for use in screens for small molecules that rescue PMM2 deficiency. As described below, we successfully developed screen-ready yeast models that mirror two...
by Ethan Perlstein | May 29, 2016 | Science |
At PLab we’re always on the lookout for new publications describing simple animal models of rare genetic diseases. The more non-obvious the model/disease fit appears at first blush, the more exciting are any results that confirm therapeutic relevance in humans...
by Nina DiPrimio | May 26, 2015 | Science |
There are many research examples of yeast genes that were replaced by human orthologs for protein characterization, some of which with direct human disease relevance. One excellent example is out of Berkeley by researchers from the Rine lab published in 2012 where...
